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Mar 29 2016

ContraVir Pharma (CTRV) Says its CMX157 Outperforms Gilead’s TAF; Shares Gain

About Broad Street Alerts:  — ContraVir Pharma (CTRV)

 

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ContraVir Pharma (CTRV)

ContraVir Pharmaceuticals, a biopharmaceutical with a market cap of just over $50 million, gained 30% Tuesday morning after it said its CMX157 outperforms Gilead’s (Nasdaq: GILD) Tenofovir AF (TAF) in Hepatitis B virus.

The company’s press release said:

ContraVir Pharmaceuticals, Inc. (NASDAQ: CTRV), a biopharmaceutical company focused on the development and commercialization of targeted antiviral therapies, reported positive results from a third-party in vitro study that further validates CMX157’s profile as a highly potent anti-hepatitis B drug. In this first head-to-head in vitro study, CMX157 compared favorably to tenofovir alafenamide fumarate (TAF), which was approved recently by the US Food and Drug Administration (FDA) as part of a four-drug combination therapy for HIV-1 (Genvoya®), and is currently under development by Gilead Sciences Inc. (GILD) for treating chronic hepatitis B infection. ContraVir recently initiated a Phase 1/2a clinical study of CMX157, which is currently enrolling healthy volunteers and is anticipated to begin enrolling hepatitis B patients in the second quarter 2016.

The study compared the anti-hepatitis B activities of CMX157 and other tenofovir prodrugs, including tenofovir DF (Viread®), in order to profile CMX157 among this important class of antiviral therapies. The study findings revealed that CMX157 and TAF were similarly potent against hepatitis B virus (HBV), with CMX157 trending toward higher potency (EC50 = 9.3 ± 3.6 nM vs. 32.4 ± 17.1 nM for CMX157 and TAF, respectively; and EC90 = 186 ± 53 nM vs 474 ± 261 nM for CMX157 and TAF, respectively). Furthermore, viral rebound studies showed that CMX157 demonstrates best-in-class duration of activity. Nine days following incubation with HBV, using two different experimental conditions, one at equimolar and one at EC90 concentrations, CMX157 showed two- to three-fold reduced viral rebound compared to TAF. The study also confirmed earlier results, as reported previously by ContraVir, regarding the significantly increased potency of CMX157 compared to tenofovir.

 

 

 

 

Source : Street Insider

 

SCS LLC has not been compensated for this article.

SCS LLC was previously compensated up to twenty thousand dollars each by star media llc for the mention of INVT and XXII however those contracts have expired.

Written by broadAdmin · Categorized: Uncategorized

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